Assay Detail
Binding
CHEMBL4121164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MERS-CoV spike protein Q1020R mutant mediated cell-cell fusion between viral protein expressing human 293T cells and human HuH7 target cells assessed as decrease in pseudovirus infection preincubated with virus for 1 hr followed by HuH7 cells addition measured after 48 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.89 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127413 | — | — | 1 | 6.19 |
| CHEMBL4126311 | — | — | 1 | 6.05 |
| CHEMBL4130273 | — | — | 1 | 5.70 |
| CHEMBL4127619 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127413 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4126311 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4130273 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4127619 | — | EC50 | = | 2490.0 | nM | 5.60 |