Assay Detail
Binding
CHEMBL4121223
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Binding affinity to recombinant human N-terminal NLuc-tagged P2Y2R expressed in human 1321N1 cells incubated for 1 hr in presence of AR-C118925 by furimazine-based NanoBRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 5.97 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127889 | — | — | 1 | 7.05 |
| CHEMBL4128532 | — | — | 1 | 6.89 |
| CHEMBL4128024 | — | — | 1 | 6.53 |
| CHEMBL4126655 | — | — | 1 | 6.32 |
| CHEMBL4125853 | — | — | 1 | 6.12 |
| CHEMBL4125987 | — | — | 1 | 6.07 |
| CHEMBL4125833 | — | — | 1 | 6.05 |
| CHEMBL4127230 | — | — | 1 | 5.78 |
| CHEMBL4128318 | — | — | 1 | 5.67 |
| CHEMBL4126826 | — | — | 1 | 5.56 |
| CHEMBL4129129 | — | — | 1 | 5.38 |
| CHEMBL4129299 | — | — | 1 | 5.29 |
| CHEMBL4129692 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127889 | — | Kd | = | 89.13 | nM | 7.05 |
| CHEMBL4128532 | — | Kd | = | 128.82 | nM | 6.89 |
| CHEMBL4128024 | — | Kd | = | 295.12 | nM | 6.53 |
| CHEMBL4126655 | — | Kd | = | 478.63 | nM | 6.32 |
| CHEMBL4125853 | — | Kd | = | 758.58 | nM | 6.12 |
| CHEMBL4125987 | — | Kd | = | 851.14 | nM | 6.07 |
| CHEMBL4125833 | — | Kd | = | 891.25 | nM | 6.05 |
| CHEMBL4127230 | — | Kd | = | 1659.59 | nM | 5.78 |
| CHEMBL4128318 | — | Kd | = | 2137.96 | nM | 5.67 |
| CHEMBL4126826 | — | Kd | = | 2754.23 | nM | 5.56 |
| CHEMBL4129129 | — | Kd | = | 4168.69 | nM | 5.38 |
| CHEMBL4129299 | — | Kd | = | 5128.61 | nM | 5.29 |
| CHEMBL4129692 | — | Kd | = | 12302.69 | nM | 4.91 |