Assay Detail
Binding
CHEMBL4121235
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Inhibition of ALK L1196M mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Lipophilic Efficiency as an Important Metric in Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.78 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3286830 | LORLATINIB | 4.0 | 1 | 9.15 |
| CHEMBL4130209 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3286830 | LORLATINIB | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4130209 | — | Ki | = | 4.0 | nM | 8.40 |