Assay Detail
Binding
CHEMBL4121633
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Inhibition of HCV NS5A in HCV genotype 2b assessed as reduction in viral replication by cell based replicon assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.85 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763799 | — | — | 1 | 7.11 |
| CHEMBL3765513 | — | — | 1 | 6.90 |
| CHEMBL3765311 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763799 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3765513 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3765311 | — | EC50 | = | 286.0 | nM | 6.54 |