Assay Detail
Binding
CHEMBL4121732
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Inhibition of JNK1 (unknown origin)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.08 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128114 | — | — | 1 | 7.20 |
| CHEMBL4125907 | — | — | 1 | 7.10 |
| CHEMBL4127140 | — | — | 1 | 6.90 |
| CHEMBL4127479 | — | — | 1 | 6.80 |
| CHEMBL4129362 | — | — | 1 | 6.80 |
| CHEMBL4126095 | — | — | 1 | 6.70 |
| CHEMBL4127977 | — | — | 1 | 6.70 |
| CHEMBL4128717 | — | — | 1 | 6.60 |
| CHEMBL4128939 | — | — | 1 | 6.50 |
| CHEMBL4127319 | — | — | 1 | 6.40 |
| CHEMBL4129791 | — | — | 1 | 6.20 |
| CHEMBL4130310 | — | — | 1 | 6.20 |
| CHEMBL4126740 | — | — | 1 | 6.20 |
| CHEMBL4125774 | — | — | 1 | 6.20 |
| CHEMBL4126566 | — | — | 1 | 6.00 |
| CHEMBL4127640 | — | — | 1 | 5.80 |
| CHEMBL4129040 | — | — | 1 | 5.70 |
| CHEMBL4126511 | — | — | 1 | 5.70 |
| CHEMBL4128577 | — | — | 1 | 5.70 |
| CHEMBL4129590 | — | — | 1 | 5.50 |
| CHEMBL4129219 | — | — | 1 | 5.50 |
| CHEMBL4127797 | — | — | 1 | 5.50 |
| CHEMBL4126300 | — | — | 1 | 5.30 |
| CHEMBL4127330 | — | — | 1 | 5.20 |
| CHEMBL4128459 | — | — | 1 | 5.10 |
| CHEMBL4127076 | — | — | 1 | 4.70 |
| CHEMBL4128540 | — | — | 1 | - |
| CHEMBL4129941 | — | — | 1 | - |
| CHEMBL4129843 | — | — | 1 | - |
| CHEMBL4129991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128114 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4125907 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4127140 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4127479 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4129362 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4126095 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4127977 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4128717 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4128939 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4127319 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4129791 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4130310 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4126740 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4125774 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4126566 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4127640 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4129040 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4128577 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4126511 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4129590 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4129219 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4127797 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4126300 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4127330 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4128459 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4127076 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4128540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129941 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129991 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4128625 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126413 | — | IC50 | > | 10000.0 | nM | - |