Assay Detail
Binding
CHEMBL4121733
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Inhibition of PI3Kgamma (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.90 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127319 | — | — | 1 | 7.90 |
| CHEMBL4126566 | — | — | 1 | 7.00 |
| CHEMBL4129590 | — | — | 1 | 5.80 |
| CHEMBL4127640 | — | — | 1 | 5.60 |
| CHEMBL4126300 | — | — | 1 | 5.40 |
| CHEMBL4126413 | — | — | 1 | 5.20 |
| CHEMBL4129219 | — | — | 1 | 5.20 |
| CHEMBL4128625 | — | — | 1 | 5.10 |
| CHEMBL4129843 | — | — | 1 | - |
| CHEMBL4129991 | — | — | 1 | - |
| CHEMBL4129040 | — | — | 1 | - |
| CHEMBL4127797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127319 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL4126566 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4129590 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4127640 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4126300 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4126413 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4129219 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4128625 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4129843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129991 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129040 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4127797 | — | IC50 | > | 10000.0 | nM | - |