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Assay Detail

CHEMBL4121749

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant full-length bacterial His6-tagged VIM2 (27 to 266 residues) expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacteria
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ.
Bioorg Med Chem (2018) 26 : 2928 -2936
PubMed 29655609 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 59 5.58 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4127736 — — 1 7.52
CHEMBL3792857 — — 1 7.40
CHEMBL4127821 — — 1 7.30
CHEMBL4126149 — — 1 7.30
CHEMBL4068716 — — 1 7.22
CHEMBL4129411 — — 1 7.16
CHEMBL4128221 — — 1 7.00
CHEMBL4125829 — — 1 6.70
CHEMBL4129450 — — 1 6.70
CHEMBL4126465 — — 1 6.52
CHEMBL1559342 — — 1 6.52
CHEMBL3221923 — — 1 6.40
CHEMBL4129233 — — 1 6.40
CHEMBL4129039 — — 1 6.40
CHEMBL4095898 — — 1 6.40
CHEMBL4126927 — — 1 6.30
CHEMBL4126780 — — 1 6.22
CHEMBL4129222 — — 1 6.10
CHEMBL4125695 — — 1 5.89
CHEMBL4125965 — — 1 5.82
CHEMBL1605498 — — 1 5.70
CHEMBL4126589 — — 1 5.58
CHEMBL3221924 — — 1 5.57
CHEMBL3221922 — — 1 5.48
CHEMBL3221925 — — 1 5.46
CHEMBL4128032 — — 1 5.44
CHEMBL4126745 — — 1 5.23
CHEMBL1451326 — — 1 5.21
CHEMBL4126842 — — 1 5.17
CHEMBL4129281 — — 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4127736 — IC50 = 30.0 nM 7.52
CHEMBL3792857 — IC50 = 40.0 nM 7.40
CHEMBL4126149 — IC50 = 50.0 nM 7.30
CHEMBL4127821 — IC50 = 50.0 nM 7.30
CHEMBL4068716 — IC50 = 60.0 nM 7.22
CHEMBL4129411 — IC50 = 70.0 nM 7.16
CHEMBL4128221 — IC50 = 100.0 nM 7.00
CHEMBL4125829 — IC50 = 200.0 nM 6.70
CHEMBL4129450 — IC50 = 200.0 nM 6.70
CHEMBL4126465 — IC50 = 300.0 nM 6.52
CHEMBL1559342 — IC50 = 300.0 nM 6.52
CHEMBL4095898 — IC50 = 400.0 nM 6.40
CHEMBL4129039 — IC50 = 400.0 nM 6.40
CHEMBL4129233 — IC50 = 400.0 nM 6.40
CHEMBL3221923 — IC50 = 400.0 nM 6.40
CHEMBL4126927 — IC50 = 500.0 nM 6.30
CHEMBL4126780 — IC50 = 600.0 nM 6.22
CHEMBL4129222 — IC50 = 800.0 nM 6.10
CHEMBL4125695 — IC50 = 1300.0 nM 5.89
CHEMBL4125965 — IC50 = 1500.0 nM 5.82
CHEMBL1605498 — IC50 = 2000.0 nM 5.70
CHEMBL4126589 — IC50 = 2600.0 nM 5.58
CHEMBL3221924 — IC50 = 2700.0 nM 5.57
CHEMBL3221922 — IC50 = 3300.0 nM 5.48
CHEMBL3221925 — IC50 = 3500.0 nM 5.46
CHEMBL4128032 — IC50 = 3600.0 nM 5.44
CHEMBL4126745 — IC50 = 5900.0 nM 5.23
CHEMBL1451326 — IC50 = 6200.0 nM 5.21
CHEMBL4126842 — IC50 = 6700.0 nM 5.17
CHEMBL4129281 — IC50 = 6800.0 nM 5.17
CHEMBL4129136 — IC50 = 7600.0 nM 5.12
CHEMBL3221932 — IC50 = 9400.0 nM 5.03
CHEMBL4128796 — IC50 = 9800.0 nM 5.01
CHEMBL3221930 — IC50 = 9700.0 nM 5.01
CHEMBL4129315 — IC50 = 11400.0 nM 4.94
CHEMBL3234727 — IC50 = 12900.0 nM 4.89
CHEMBL4126874 — IC50 = 16400.0 nM 4.79
CHEMBL4127636 — IC50 = 17600.0 nM 4.75
CHEMBL4128178 — IC50 = 18700.0 nM 4.73
CHEMBL4126798 — IC50 = 29400.0 nM 4.53
CHEMBL4127551 — IC50 = 32000.0 nM 4.50
CHEMBL1173347 — IC50 = 34500.0 nM 4.46
CHEMBL4129749 — IC50 = 36900.0 nM 4.43
CHEMBL66070 — IC50 = 36800.0 nM 4.43
CHEMBL4130010 — IC50 = 37600.0 nM 4.42
CHEMBL4126979 — IC50 = 38700.0 nM 4.41
CHEMBL4128976 — IC50 = 39500.0 nM 4.40
CHEMBL4127204 — IC50 = 41700.0 nM 4.38
CHEMBL4130192 — IC50 = 41800.0 nM 4.38
CHEMBL4126603 — IC50 = 44000.0 nM 4.36