Assay Detail
Binding
CHEMBL4121750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aeromonas hydrophila CphA using fluorogenic cephalosporin as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aeromonas hydrophila |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metallo-beta-lactamase type 2 (CHEMBL1169593) ↗| Type | SINGLE PROTEIN |
| Organism | Aeromonas hydrophila |
Publication
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3792857 | — | — | 1 | 6.70 |
| CHEMBL4095898 | — | — | 1 | 5.68 |
| CHEMBL3234727 | — | — | 1 | 4.15 |
| CHEMBL4126979 | — | — | 1 | - |
| CHEMBL4068716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3792857 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4095898 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3234727 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4126979 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4068716 | — | IC50 | > | 50000.0 | nM | - |