Assay Detail
Functional
CHEMBL4121822
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Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.63 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129059 | — | — | 1 | 5.03 |
| CHEMBL4130006 | — | — | 1 | 4.79 |
| CHEMBL4126584 | — | — | 1 | 4.76 |
| CHEMBL4129216 | — | — | 1 | 4.76 |
| CHEMBL4126737 | — | — | 1 | 4.68 |
| CHEMBL4128242 | — | — | 1 | 4.68 |
| CHEMBL4127689 | — | — | 1 | 4.68 |
| CHEMBL4129534 | — | — | 1 | 4.67 |
| CHEMBL4125771 | — | — | 1 | 4.67 |
| CHEMBL4129390 | — | — | 1 | 4.66 |
| CHEMBL4128568 | — | — | 1 | 4.66 |
| CHEMBL4127181 | — | — | 1 | 4.66 |
| CHEMBL4127975 | — | — | 1 | 4.65 |
| CHEMBL4126865 | — | — | 1 | 4.64 |
| CHEMBL4126083 | — | — | 1 | 4.61 |
| CHEMBL4129765 | — | — | 1 | 4.59 |
| CHEMBL4128155 | — | — | 1 | 4.58 |
| CHEMBL4128418 | — | — | 1 | 4.55 |
| CHEMBL4128398 | — | — | 1 | 4.53 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.40 |
| CHEMBL4125942 | — | — | 1 | 4.36 |
| CHEMBL4127394 | — | — | 1 | 4.35 |
| CHEMBL4127846 | — | — | 1 | - |
| CHEMBL4127815 | — | — | 1 | - |
| CHEMBL4127321 | — | — | 1 | - |
| CHEMBL4129783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129059 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL4130006 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL4126584 | — | IC50 | = | 17190.0 | nM | 4.76 |
| CHEMBL4129216 | — | IC50 | = | 17380.0 | nM | 4.76 |
| CHEMBL4126737 | — | IC50 | = | 21020.0 | nM | 4.68 |
| CHEMBL4128242 | — | IC50 | = | 21020.0 | nM | 4.68 |
| CHEMBL4127689 | — | IC50 | = | 20690.0 | nM | 4.68 |
| CHEMBL4129534 | — | IC50 | = | 21420.0 | nM | 4.67 |
| CHEMBL4125771 | — | IC50 | = | 21520.0 | nM | 4.67 |
| CHEMBL4129390 | — | IC50 | = | 21980.0 | nM | 4.66 |
| CHEMBL4128568 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4127181 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4127975 | — | IC50 | = | 22220.0 | nM | 4.65 |
| CHEMBL4126865 | — | IC50 | = | 22780.0 | nM | 4.64 |
| CHEMBL4126083 | — | IC50 | = | 24850.0 | nM | 4.61 |
| CHEMBL4129765 | — | IC50 | = | 25960.0 | nM | 4.59 |
| CHEMBL4128155 | — | IC50 | = | 26240.0 | nM | 4.58 |
| CHEMBL4128418 | — | IC50 | = | 28410.0 | nM | 4.55 |
| CHEMBL4128398 | — | IC50 | = | 29270.0 | nM | 4.53 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 39860.0 | nM | 4.40 |
| CHEMBL4125942 | — | IC50 | = | 43660.0 | nM | 4.36 |
| CHEMBL4127394 | — | IC50 | = | 44210.0 | nM | 4.35 |
| CHEMBL4127846 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127815 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127321 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4129783 | — | IC50 | > | 50000.0 | nM | - |