Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4121825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity in mouse B16/F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16-F10
Confidence 1 — Organism
Curated By Intermediate

Target

B16-F10 (CHEMBL612656)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents.
Tokala R, Bale S, Janrao IP, Vennela A, Kumar NP, Senwar KR, Godugu C, Shankaraiah N.
Bioorg Med Chem Lett (2018) 28 : 1919 -1924
PubMed 29657100 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.62 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4129059 1 5.35
CHEMBL4126737 1 5.25
CHEMBL4130006 1 5.07
CHEMBL4127689 1 4.68
CHEMBL4128242 1 4.68
CHEMBL4129216 1 4.68
CHEMBL4128155 1 4.66
CHEMBL4128418 1 4.64
CHEMBL4126083 1 4.63
CHEMBL4126584 1 4.61
CHEMBL4129765 1 4.54
CHEMBL4127815 1 4.53
CHEMBL4127975 1 4.53
CHEMBL4127181 1 4.51
CHEMBL4129390 1 4.51
CHEMBL4129783 1 4.46
CHEMBL4128568 1 4.45
CHEMBL4127321 1 4.45
CHEMBL4125942 1 4.40
CHEMBL4125771 1 4.40
CHEMBL4127394 1 4.38
CHEMBL4126865 1 4.33
CHEMBL4129534 1 -
CHEMBL4128398 1 -
CHEMBL4127846 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4129059 IC50 = 4510.0 nM 5.35
CHEMBL4126737 IC50 = 5620.0 nM 5.25
CHEMBL4130006 IC50 = 8540.0 nM 5.07
CHEMBL4127689 IC50 = 21030.0 nM 4.68
CHEMBL4128242 IC50 = 20670.0 nM 4.68
CHEMBL4129216 IC50 = 20710.0 nM 4.68
CHEMBL4128155 IC50 = 22070.0 nM 4.66
CHEMBL4128418 IC50 = 22900.0 nM 4.64
CHEMBL4126083 IC50 = 23650.0 nM 4.63
CHEMBL4126584 IC50 = 24710.0 nM 4.61
CHEMBL4129765 IC50 = 28850.0 nM 4.54
CHEMBL4127815 IC50 = 29380.0 nM 4.53
CHEMBL4127975 IC50 = 29880.0 nM 4.53
CHEMBL4127181 IC50 = 31080.0 nM 4.51
CHEMBL4129390 IC50 = 31000.0 nM 4.51
CHEMBL4129783 IC50 = 34720.0 nM 4.46
CHEMBL4128568 IC50 = 35190.0 nM 4.45
CHEMBL4127321 IC50 = 35800.0 nM 4.45
CHEMBL4125942 IC50 = 39670.0 nM 4.40
CHEMBL4125771 IC50 = 39480.0 nM 4.40
CHEMBL4127394 IC50 = 42160.0 nM 4.38
CHEMBL4126865 IC50 = 46780.0 nM 4.33
CHEMBL4129534 IC50 > 50000.0 nM -
CHEMBL4128398 IC50 > 50000.0 nM -
CHEMBL4127846 IC50 > 50000.0 nM -