Assay Detail
Binding
CHEMBL4122466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (CHEMBL4425) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126270 | — | — | 1 | 8.35 |
| CHEMBL4128481 | — | — | 1 | 8.04 |
| CHEMBL4127641 | — | — | 1 | 7.68 |
| CHEMBL4128897 | — | — | 1 | 7.57 |
| CHEMBL3601554 | — | — | 1 | 7.46 |
| CHEMBL4127499 | — | — | 1 | 7.28 |
| CHEMBL4129844 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126270 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4128481 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4127641 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4128897 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3601554 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4127499 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4129844 | — | IC50 | = | 596.0 | nM | 6.22 |