Assay Detail
Functional
CHEMBL4122674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against imatinib-susceptible human GIST882 cells harboring c-KIT K642E mutant after 96 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.79 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258402 | — | — | 1 | 5.80 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.77 |
| CHEMBL336434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258402 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL941 | IMATINIB | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL336434 | — | IC50 | > | 25000.0 | nM | - |