Assay Detail
Functional
CHEMBL4122678
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Antiproliferative activity against human HGC27 cells after 96 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.09 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258402 | — | — | 1 | 7.00 |
| CHEMBL336434 | — | — | 1 | 5.64 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258402 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL336434 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL941 | IMATINIB | IC50 | = | 2400.0 | nM | 5.62 |