Assay Detail
Binding
CHEMBL4122763
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Inhibition of hedgehog signaling pathway in mouse Light2 cells after 48 hrs by Gli-luciferase reporter gene assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.75 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2142592 | TALADEGIB | 2.0 | 1 | 8.65 |
| CHEMBL4127045 | — | — | 1 | 8.63 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.61 |
| CHEMBL4127215 | — | — | 1 | 8.15 |
| CHEMBL4129815 | — | — | 1 | 8.07 |
| CHEMBL4128598 | — | — | 1 | 7.92 |
| CHEMBL4130172 | — | — | 1 | 7.78 |
| CHEMBL4128456 | — | — | 1 | 7.66 |
| CHEMBL4127648 | — | — | 1 | 7.60 |
| CHEMBL4125976 | — | — | 1 | 7.59 |
| CHEMBL4128428 | — | — | 1 | 7.52 |
| CHEMBL4128748 | — | — | 1 | 7.49 |
| CHEMBL4126595 | — | — | 1 | 7.48 |
| CHEMBL4126571 | — | — | 1 | 7.44 |
| CHEMBL4125812 | — | — | 1 | 7.44 |
| CHEMBL4127985 | — | — | 1 | 7.37 |
| CHEMBL4129682 | — | — | 1 | 7.37 |
| CHEMBL4127353 | — | — | 1 | 7.36 |
| CHEMBL4127827 | — | — | 1 | 7.21 |
| CHEMBL4129067 | — | — | 1 | - |
| CHEMBL4127192 | — | — | 1 | - |
| CHEMBL4126276 | — | — | 1 | - |
| CHEMBL4129230 | — | — | 1 | - |
| CHEMBL4125787 | — | — | 1 | - |
| CHEMBL4130286 | — | — | 1 | - |
| CHEMBL4127019 | — | — | 1 | - |
| CHEMBL4126872 | — | — | 1 | - |
| CHEMBL4128253 | — | — | 1 | - |
| CHEMBL4127611 | — | — | 1 | - |
| CHEMBL4126238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2142592 | TALADEGIB | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL4127045 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL4127215 | — | IC50 | = | 7.02 | nM | 8.15 |
| CHEMBL4129815 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4128598 | — | IC50 | = | 12.15 | nM | 7.92 |
| CHEMBL4130172 | — | IC50 | = | 16.61 | nM | 7.78 |
| CHEMBL4128456 | — | IC50 | = | 21.96 | nM | 7.66 |
| CHEMBL4127648 | — | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL4125976 | — | IC50 | = | 25.52 | nM | 7.59 |
| CHEMBL4128428 | — | IC50 | = | 29.99 | nM | 7.52 |
| CHEMBL4128748 | — | IC50 | = | 32.46 | nM | 7.49 |
| CHEMBL4126595 | — | IC50 | = | 32.84 | nM | 7.48 |
| CHEMBL4126571 | — | IC50 | = | 36.47 | nM | 7.44 |
| CHEMBL4125812 | — | IC50 | = | 36.39 | nM | 7.44 |
| CHEMBL4127985 | — | IC50 | = | 42.91 | nM | 7.37 |
| CHEMBL4129682 | — | IC50 | = | 43.18 | nM | 7.37 |
| CHEMBL4127353 | — | IC50 | = | 43.78 | nM | 7.36 |
| CHEMBL4127827 | — | IC50 | = | 61.54 | nM | 7.21 |
| CHEMBL4129067 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4127192 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4126276 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4129230 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4125787 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4130286 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4127019 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4126872 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4128253 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4127611 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4126238 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4126389 | — | IC50 | > | 100.0 | nM | - |