Assay Detail
Binding
CHEMBL4122798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant His6-tagged human PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.72 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129001 | — | — | 2 | 4.72 |
| CHEMBL1438938 | — | — | 1 | - |
| CHEMBL4129789 | — | — | 1 | - |
| CHEMBL4125748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129001 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4129001 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL1438938 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4129789 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4125748 | — | IC50 | > | 100000.0 | nM | - |