Assay Detail
Binding
CHEMBL4122880
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Inhibition of renin in human plasma by radioimmunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.73 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129081 | — | — | 1 | 9.40 |
| CHEMBL3958809 | — | — | 1 | 9.10 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.08 |
| CHEMBL4127842 | — | — | 1 | 8.96 |
| CHEMBL4126453 | — | — | 1 | 8.92 |
| CHEMBL4130109 | — | — | 1 | 8.92 |
| CHEMBL4129865 | — | — | 1 | 8.89 |
| CHEMBL4127686 | — | — | 1 | 8.89 |
| CHEMBL3990145 | IMARIKIREN | 2.0 | 1 | 8.85 |
| CHEMBL4130200 | — | — | 1 | 8.82 |
| CHEMBL4128795 | — | — | 1 | 8.59 |
| CHEMBL4129831 | — | — | 1 | 8.55 |
| CHEMBL4127179 | — | — | 1 | 8.54 |
| CHEMBL4126609 | — | — | 1 | 8.48 |
| CHEMBL4128929 | — | — | 1 | 8.47 |
| CHEMBL4125900 | — | — | 1 | 8.40 |
| CHEMBL4126136 | — | — | 1 | 8.27 |
| CHEMBL4128438 | — | — | 1 | 8.04 |
| CHEMBL3889771 | — | — | 1 | - |
| CHEMBL4127516 | — | — | 1 | - |
| CHEMBL4128342 | — | — | 1 | - |
| CHEMBL4126556 | — | — | 1 | - |
| CHEMBL4129207 | — | — | 1 | - |
| CHEMBL4126759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129081 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3958809 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4127842 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4126453 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4130109 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4129865 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4127686 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3990145 | IMARIKIREN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4130200 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4128795 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4129831 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4127179 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4126609 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4128929 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4125900 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4126136 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4128438 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL3889771 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL4127516 | — | IC50 | - | — | - | |
| CHEMBL4128342 | — | IC50 | - | — | - | |
| CHEMBL4126556 | — | IC50 | - | — | - | |
| CHEMBL4129207 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL4126759 | — | IC50 | > | 10.0 | nM | - |