Assay Detail
Binding
CHEMBL4122888
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Inhibition of renin in rat plasma
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.79 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 7.06 |
| CHEMBL3990145 | IMARIKIREN | 2.0 | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1639 | ALISKIREN | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3990145 | IMARIKIREN | IC50 | = | 310.0 | nM | 6.51 |