Assay Detail
Binding
CHEMBL4123079
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Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility shift assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.55 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130288 | — | — | 1 | 9.00 |
| CHEMBL4128972 | — | — | 1 | 8.70 |
| CHEMBL4127020 | — | — | 1 | 8.70 |
| CHEMBL4127743 | — | — | 1 | 8.70 |
| CHEMBL4126661 | — | — | 1 | 8.52 |
| CHEMBL4127735 | — | — | 1 | 8.52 |
| CHEMBL4127894 | — | — | 1 | 8.30 |
| CHEMBL4129134 | — | — | 1 | 8.22 |
| CHEMBL4129266 | — | — | 1 | 8.15 |
| CHEMBL4129143 | — | — | 1 | 8.15 |
| CHEMBL4129231 | — | — | 1 | 7.58 |
| CHEMBL4126502 | — | — | 1 | 7.57 |
| CHEMBL4129070 | — | — | 1 | 7.52 |
| CHEMBL4125954 | — | — | 1 | 7.46 |
| CHEMBL4127193 | — | — | 1 | 6.77 |
| CHEMBL4125788 | — | — | 1 | 6.52 |
| CHEMBL4126784 | — | — | 1 | 5.92 |
| CHEMBL4129402 | — | — | 1 | 5.68 |
| CHEMBL4127829 | — | — | 1 | 5.64 |
| CHEMBL4125815 | — | — | 1 | 5.34 |
| CHEMBL4128164 | — | — | 1 | - |
| CHEMBL4129930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130288 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4128972 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4127020 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4127743 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4126661 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4127735 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4127894 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4129134 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4129266 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4129143 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4129231 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4126502 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4129070 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4125954 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4127193 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4125788 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4126784 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4129402 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4127829 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4125815 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4128164 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129930 | — | IC50 | > | 10000.0 | nM | - |