Assay Detail
ADMET
CHEMBL4123080
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Inhibition of full length recombinant human HDAC6 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.44 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128164 | — | — | 1 | 8.70 |
| CHEMBL4129402 | — | — | 1 | 8.40 |
| CHEMBL4125815 | — | — | 1 | 7.09 |
| CHEMBL4129070 | — | — | 1 | 5.55 |
| CHEMBL4126784 | — | — | 1 | - |
| CHEMBL4127193 | — | — | 1 | - |
| CHEMBL4126661 | — | — | 1 | - |
| CHEMBL4129930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128164 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4129402 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4125815 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4129070 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4126784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4127193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129930 | — | IC50 | > | 10000.0 | nM | - |