Assay Detail
Binding
CHEMBL4123084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoLuc-tagged HDAC11 (unknown origin) by BRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.33 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127735 | — | — | 1 | 7.92 |
| CHEMBL4126661 | — | — | 1 | 7.82 |
| CHEMBL4128972 | — | — | 1 | 7.70 |
| CHEMBL4127894 | — | — | 1 | 7.07 |
| CHEMBL4129134 | — | — | 1 | 6.89 |
| CHEMBL4126502 | — | — | 1 | 6.57 |
| CHEMBL4127020 | — | — | 1 | - |
| CHEMBL4130288 | — | — | 1 | - |
| CHEMBL4129930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127735 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4126661 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4128972 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4127894 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4129134 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4126502 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4127020 | — | IC50 | - | — | - | |
| CHEMBL4130288 | — | IC50 | - | — | - | |
| CHEMBL4129930 | — | IC50 | > | 25000.0 | nM | - |