Assay Detail
Binding
CHEMBL4123650
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Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human serum albumin
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.53 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130252 | — | — | 1 | 8.52 |
| CHEMBL4128890 | — | — | 1 | 8.22 |
| CHEMBL4130102 | — | — | 1 | 8.15 |
| CHEMBL4128240 | — | — | 1 | 8.10 |
| CHEMBL4126840 | — | — | 1 | 7.92 |
| CHEMBL4128924 | — | — | 1 | 7.85 |
| CHEMBL4126289 | — | — | 1 | 7.77 |
| CHEMBL4129717 | — | — | 1 | 7.72 |
| CHEMBL4127923 | — | — | 1 | 7.72 |
| CHEMBL4127873 | — | — | 1 | 7.68 |
| CHEMBL4126659 | — | — | 1 | 7.57 |
| CHEMBL4127891 | — | — | 1 | 7.08 |
| CHEMBL4127663 | — | — | 1 | 7.05 |
| CHEMBL4126165 | — | — | 1 | 6.83 |
| CHEMBL4126686 | — | — | 1 | 6.25 |
| CHEMBL4128715 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130252 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4128890 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4130102 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4128240 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4126840 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4128924 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4126289 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4129717 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4127923 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4127873 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4126659 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4127891 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4127663 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4126165 | — | EC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4126686 | — | EC50 | = | 557.0 | nM | 6.25 |
| CHEMBL4128715 | — | EC50 | = | 857.0 | nM | 6.07 |