Assay Detail
Binding
CHEMBL4123713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Norovirus prototypic GI.1 3CL protease using HiLyte Fluor 488-labelled DFELQGPK as substrate incubated for 90 mins measured every mins for 20 mins by FRET assay
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Norovirus GI.1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Nonstructural polyprotein (CHEMBL4295553) ↗| Type | SINGLE PROTEIN |
| Organism | Norovirus Hu/GI/10360/2010/VNM |
Publication
Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.64 | 7.50 |
| IC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441741 | — | — | 2 | 7.50 |
| CHEMBL4129318 | — | — | 2 | 7.10 |
| CHEMBL4128616 | — | — | 2 | 6.23 |
| CHEMBL4128223 | — | — | 2 | 6.18 |
| CHEMBL4127236 | — | — | 2 | 6.18 |
| CHEMBL4128485 | — | — | 2 | - |
| CHEMBL4125865 | — | — | 2 | - |
| CHEMBL4127247 | — | — | 2 | - |
| CHEMBL4126005 | — | — | 2 | - |
| CHEMBL4128073 | — | — | 2 | - |
| CHEMBL4129451 | — | — | 2 | - |
| CHEMBL4126846 | — | — | 2 | - |
| CHEMBL4127374 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441741 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4129318 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4128616 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL4128223 | — | IC50 | = | 654.0 | nM | 6.18 |
| CHEMBL4127236 | — | IC50 | = | 654.0 | nM | 6.18 |
| CHEMBL4128485 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4125865 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127247 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4126005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4128073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127374 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4128485 | — | IC90 | - | — | - | |
| CHEMBL4125865 | — | IC90 | - | — | - | |
| CHEMBL4127247 | — | IC90 | - | — | - | |
| CHEMBL4129318 | — | IC90 | = | 155.0 | nM | - |
| CHEMBL4126005 | — | IC90 | - | — | - | |
| CHEMBL4128073 | — | IC90 | - | — | - | |
| CHEMBL4129451 | — | IC90 | - | — | - | |
| CHEMBL4126846 | — | IC90 | - | — | - | |
| CHEMBL4128223 | — | IC90 | = | 2241.0 | nM | - |
| CHEMBL4128616 | — | IC90 | = | 1697.0 | nM | - |
| CHEMBL4127236 | — | IC90 | = | 2241.0 | nM | - |
| CHEMBL4127374 | — | IC90 | - | — | - | |
| CHEMBL2441741 | — | IC90 | = | 248.0 | nM | - |