Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4123714

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Norovirus prototypic GI.1 infected in human HG23 cells assessed as inhibition of viral RNA replication after 4 days by RT-qPCR method
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Norovirus GI.1
Confidence 1 — Organism
Curated By Intermediate

Target

Norovirus (CHEMBL4296584)
Type ORGANISM
Organism Norovirus

Publication

Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.
Amblard F, Zhou S, Liu P, Yoon J, Cox B, Muzzarelli K, Kuiper BD, Kovari LC, Schinazi RF.
Bioorg Med Chem Lett (2018) 28 : 2165 -2170
PubMed 29779977 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.90 6.41
EC90 13 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4128223 2 6.41
CHEMBL4127236 2 6.41
CHEMBL4129318 2 6.38
CHEMBL4128616 2 6.12
CHEMBL2441741 2 5.95
CHEMBL4128073 2 5.36
CHEMBL4126005 2 5.33
CHEMBL4128485 2 5.21
CHEMBL4125865 2 -
CHEMBL4127247 2 -
CHEMBL4129451 2 -
CHEMBL4126846 2 -
CHEMBL4127374 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4127236 EC50 = 390.0 nM 6.41
CHEMBL4128223 EC50 = 390.0 nM 6.41
CHEMBL4129318 EC50 = 420.0 nM 6.38
CHEMBL4128616 EC50 = 750.0 nM 6.12
CHEMBL2441741 EC50 = 1130.0 nM 5.95
CHEMBL4128073 EC50 = 4330.0 nM 5.36
CHEMBL4126005 EC50 = 4700.0 nM 5.33
CHEMBL4128485 EC50 = 6190.0 nM 5.21
CHEMBL4125865 EC50 > 10000.0 nM -
CHEMBL4127247 EC50 - -
CHEMBL4129451 EC50 > 10000.0 nM -
CHEMBL4126846 EC50 > 10000.0 nM -
CHEMBL4127374 EC50 > 10000.0 nM -
CHEMBL2441741 EC90 = 8.36 uM -
CHEMBL4128485 EC90 = 17.34 uM -
CHEMBL4125865 EC90 - -
CHEMBL4127247 EC90 - -
CHEMBL4127236 EC90 = 2.45 uM -
CHEMBL4128616 EC90 = 7.82 uM -
CHEMBL4128223 EC90 = 2.45 uM -
CHEMBL4126846 EC90 - -
CHEMBL4129451 EC90 - -
CHEMBL4128073 EC90 > 20.0 uM -
CHEMBL4126005 EC90 > 10.0 uM -
CHEMBL4127374 EC90 - -
CHEMBL4129318 EC90 = 0.92 uM -