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Assay Detail

CHEMBL4123731

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli AmpC using CENTA as substrate by spectrometry based Lineweaver-Burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Beta-lactamase (CHEMBL2026)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Boronic acid inhibitors of the class A β-lactamase KPC-2.
Zhou J, Stapleton P, Haider S, Healy J.
Bioorg Med Chem (2018) 26 : 2921 -2927
PubMed 29784271 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.30 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3613796 1 10.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3613796 Ki = 0.05 nM 10.30