Assay Detail
ADMET
CHEMBL4124194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK2 (unknown origin) expressed in HEK cells by NanoBRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.66 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125719 | — | — | 1 | 6.20 |
| CHEMBL4128266 | — | — | 1 | 5.11 |
| CHEMBL4128181 | — | — | 1 | - |
| CHEMBL4125861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125719 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4128266 | — | EC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL4128181 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4125861 | — | EC50 | > | 10000.0 | nM | - |