Assay Detail
Functional
CHEMBL4124581
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Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.14 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18028 | 5-OXO-ETE | — | 1 | 6.66 |
| CHEMBL4127146 | — | — | 1 | 6.42 |
| CHEMBL165682 | — | — | 1 | 5.81 |
| CHEMBL4130040 | — | — | 1 | 5.68 |
| CHEMBL4128214 | — | — | 1 | - |
| CHEMBL4128585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18028 | 5-OXO-ETE | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4127146 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL165682 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4130040 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4128214 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4128585 | — | EC50 | > | 100000.0 | nM | - |