Assay Detail
Functional
CHEMBL4124630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MV4-11 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.75 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 7.52 |
| CHEMBL4126750 | — | — | 1 | 6.10 |
| CHEMBL4129087 | — | — | 1 | 5.77 |
| CHEMBL4128205 | — | — | 1 | 5.58 |
| CHEMBL4128288 | — | — | 1 | 5.54 |
| CHEMBL4125914 | — | — | 1 | 5.20 |
| CHEMBL4127644 | — | — | 1 | 5.17 |
| CHEMBL4129118 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4126750 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4129087 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4128205 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4128288 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4125914 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4127644 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4129118 | — | IC50 | = | 7300.0 | nM | 5.14 |