Assay Detail
Binding
CHEMBL4124696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by patch clamp method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.78 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4107559 | — | — | 1 | 5.44 |
| CHEMBL4109308 | — | — | 1 | 5.07 |
| CHEMBL4127311 | — | — | 1 | 4.37 |
| CHEMBL4127458 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4107559 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4109308 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4127311 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL4127458 | — | IC50 | = | 59800.0 | nM | 4.22 |