Assay Detail
Binding
CHEMBL4125424
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Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.20 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243664 | ACACETIN | — | 1 | 6.72 |
| CHEMBL13045 | CHELERYTHRINE | — | 1 | 6.26 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 6.01 |
| CHEMBL28 | APIGENIN | — | 1 | 5.81 |
| CHEMBL4126384 | — | — | 1 | - |
| CHEMBL2334892 | — | — | 1 | - |
| CHEMBL470881 | OXOGLAUCINE | — | 1 | - |
| CHEMBL448891 | — | — | 1 | - |
| CHEMBL4128948 | — | — | 1 | - |
| CHEMBL4130319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243664 | ACACETIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL13045 | CHELERYTHRINE | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL28 | APIGENIN | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4126384 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2334892 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL470881 | OXOGLAUCINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL448891 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4128948 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4130319 | — | IC50 | > | 20000.0 | nM | - |