Assay Detail
Binding
CHEMBL4125475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spinal cord |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.70 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2397481 | — | — | 1 | 9.52 |
| CHEMBL108438 | — | — | 1 | 8.82 |
| CHEMBL589979 | — | — | 1 | 8.80 |
| CHEMBL4127872 | — | — | 1 | 8.74 |
| CHEMBL2396664 | — | — | 1 | 8.66 |
| CHEMBL2042018 | — | — | 1 | 8.28 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2397481 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL108438 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL589979 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4127872 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2396664 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2042018 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 8.7 | nM | 8.06 |