Assay Detail
Functional
CHEMBL4130993
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Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method
12
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.76 | 6.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426110 | — | — | 2 | 6.30 |
| CHEMBL4170979 | — | — | 1 | 6.08 |
| CHEMBL1171578 | — | — | 1 | 6.02 |
| CHEMBL4160838 | — | — | 1 | 5.82 |
| CHEMBL4159694 | — | — | 1 | 5.79 |
| CHEMBL1172319 | — | — | 1 | 5.78 |
| CHEMBL4160761 | — | — | 1 | 5.64 |
| CHEMBL4160536 | — | — | 1 | 5.50 |
| CHEMBL4166435 | — | — | 1 | 5.43 |
| CHEMBL28591 | — | — | 1 | 5.24 |
| CHEMBL704 | MESALAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426110 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4170979 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1171578 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4160838 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4159694 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL1172319 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4160761 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4160536 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4166435 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL28591 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL704 | MESALAMINE | IC50 | = | 20400000.0 | nM | - |
| CHEMBL426110 | — | Inhibition | - | % | - |