Assay Detail
Functional
CHEMBL4131015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against BRCA2 deficient Chinese hamster VC8 cells after 3 days by CCK8 or SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.58 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 8.38 |
| CHEMBL4169012 | — | — | 1 | 8.06 |
| CHEMBL4175142 | — | — | 1 | 7.50 |
| CHEMBL4162463 | — | — | 1 | 7.37 |
| CHEMBL4174278 | — | — | 1 | 7.17 |
| CHEMBL4169337 | — | — | 1 | 7.04 |
| CHEMBL4159834 | — | — | 1 | 6.86 |
| CHEMBL4172321 | — | — | 1 | 6.83 |
| CHEMBL4171279 | — | — | 1 | 6.69 |
| CHEMBL4165908 | — | — | 1 | 6.55 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 6.25 |
| CHEMBL4175790 | — | — | 1 | 6.21 |
| CHEMBL4167044 | — | — | 1 | 6.03 |
| CHEMBL4161687 | — | — | 1 | 6.01 |
| CHEMBL4167934 | — | — | 1 | 5.80 |
| CHEMBL4161414 | — | — | 1 | 5.71 |
| CHEMBL4161087 | — | — | 1 | 5.68 |
| CHEMBL4160023 | — | — | 1 | 5.48 |
| CHEMBL4167280 | — | — | 1 | 5.40 |
| CHEMBL4170665 | — | — | 1 | - |
| CHEMBL4174093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4169012 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4175142 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL4162463 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL4174278 | — | IC50 | = | 68.1 | nM | 7.17 |
| CHEMBL4169337 | — | IC50 | = | 90.1 | nM | 7.04 |
| CHEMBL4159834 | — | IC50 | = | 136.7 | nM | 6.86 |
| CHEMBL4172321 | — | IC50 | = | 148.7 | nM | 6.83 |
| CHEMBL4171279 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4165908 | — | IC50 | = | 284.2 | nM | 6.55 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 565.6 | nM | 6.25 |
| CHEMBL4175790 | — | IC50 | = | 624.3 | nM | 6.21 |
| CHEMBL4167044 | — | IC50 | = | 937.8 | nM | 6.03 |
| CHEMBL4161687 | — | IC50 | = | 987.1 | nM | 6.01 |
| CHEMBL4167934 | — | IC50 | = | 1599.3 | nM | 5.80 |
| CHEMBL4161414 | — | IC50 | = | 1944.6 | nM | 5.71 |
| CHEMBL4161087 | — | IC50 | = | 2076.1 | nM | 5.68 |
| CHEMBL4160023 | — | IC50 | = | 3287.8 | nM | 5.48 |
| CHEMBL4167280 | — | IC50 | = | 3966.3 | nM | 5.40 |
| CHEMBL4170665 | — | IC50 | < | 3.2 | nM | - |
| CHEMBL4174093 | — | IC50 | = | 0.003 | nM | - |