Assay Detail
Functional
CHEMBL4132006
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Inhibition of 17beta-estradiol-induced human MCF7 cells proliferation assessed as reduction in [3H]thymidine incorporation preincubated for 48 hrs followed by [3H]thymidine addition measured after 4 hrs by liquid scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
An overview of benzo[b]thiophene-based medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.86 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1193539 | — | — | 1 | 9.00 |
| CHEMBL42707 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1193539 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL42707 | — | IC50 | = | 190.0 | nM | 6.72 |