Assay Detail
Binding
CHEMBL4132037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental aldose reductase using glyceraldehyde as substrate in presence of NADPH
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of benzo[b]thiophene-based medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.51 |
| CHEMBL342339 | — | — | 1 | 6.92 |
| CHEMBL357460 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL342339 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL357460 | — | IC50 | = | 150.0 | nM | 6.82 |