Assay Detail
Functional
CHEMBL4132065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.18 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205190 | TRIPTONIDE | — | 1 | 7.52 |
| CHEMBL4160194 | — | — | 1 | 6.10 |
| CHEMBL4168053 | — | — | 1 | 6.10 |
| CHEMBL4163501 | — | — | 1 | 6.00 |
| CHEMBL4160131 | — | — | 1 | 5.85 |
| CHEMBL4165478 | — | — | 1 | 5.82 |
| CHEMBL4171396 | — | — | 1 | 5.72 |
| CHEMBL4170353 | — | — | 1 | 5.43 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.28 |
| CHEMBL4171453 | — | — | 1 | 5.05 |
| CHEMBL4173399 | — | — | 1 | 5.04 |
| CHEMBL4174891 | — | — | 1 | 5.02 |
| CHEMBL4167003 | — | — | 1 | 4.92 |
| CHEMBL4165133 | — | — | 1 | 4.81 |
| CHEMBL4168969 | — | — | 1 | 4.79 |
| CHEMBL4174840 | — | — | 1 | 4.71 |
| CHEMBL4161706 | — | — | 1 | 4.62 |
| CHEMBL4071529 | — | — | 1 | 4.51 |
| CHEMBL4168555 | — | — | 1 | 4.29 |
| CHEMBL4175743 | — | — | 1 | 4.28 |
| CHEMBL4166949 | — | — | 1 | 4.16 |
| CHEMBL4168110 | — | — | 1 | 4.04 |
| CHEMBL4163557 | — | — | 1 | - |
| CHEMBL4172338 | — | — | 1 | - |
| CHEMBL4170412 | — | — | 1 | - |
| CHEMBL4159770 | — | — | 1 | - |
| CHEMBL4165079 | — | — | 1 | - |
| CHEMBL4172971 | — | — | 1 | - |
| CHEMBL4174392 | — | — | 1 | - |
| CHEMBL4159723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205190 | TRIPTONIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4160194 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4168053 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4163501 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4160131 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4165478 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4171396 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4170353 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4171453 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4173399 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4174891 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4167003 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4165133 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4168969 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4174840 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4161706 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4071529 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL4168555 | — | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL4175743 | — | IC50 | = | 52110.0 | nM | 4.28 |
| CHEMBL4166949 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL4168110 | — | IC50 | = | 91100.0 | nM | 4.04 |
| CHEMBL4163557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4172338 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4170412 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4159770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4165079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4172971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4174392 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4159723 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176834 | — | IC50 | > | 100000.0 | nM | - |