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Assay Detail

CHEMBL4132293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Intermediate

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.
Zhou Y, Yan W, Cao D, Shao M, Li D, Wang F, Yang Z, Chen Y, He L, Wang T, Shen M, Chen L.
Eur J Med Chem (2017) 138 : 1114 -1125
PubMed 28763646 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.38 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4161499 1 8.49
CHEMBL4166713 1 8.41
CHEMBL4168350 1 8.18
CHEMBL4176942 1 8.18
CHEMBL4172460 1 8.04
CHEMBL4176614 1 8.02
CHEMBL4164921 1 7.81
CHEMBL4165247 1 7.73
CHEMBL107 COLCHICINE 4.0 1 7.42
CHEMBL4172099 1 7.37
CHEMBL4165657 1 7.36
CHEMBL4175866 1 7.23
CHEMBL4173581 1 7.08
CHEMBL4177003 1 7.08
CHEMBL4172091 1 7.06
CHEMBL4169079 1 7.01
CHEMBL4167665 1 6.73
CHEMBL4168737 1 6.59
CHEMBL4177343 1 6.44
CHEMBL4175945 1 6.41
CHEMBL4175532 1 6.35
CHEMBL4168750 1 -
CHEMBL4164215 1 -
CHEMBL1091825 1 -
CHEMBL4160442 1 -
CHEMBL4160815 1 -
CHEMBL4165322 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4161499 IC50 = 3.2 nM 8.49
CHEMBL4166713 IC50 = 3.9 nM 8.41
CHEMBL4168350 IC50 = 6.6 nM 8.18
CHEMBL4176942 IC50 = 6.6 nM 8.18
CHEMBL4172460 IC50 = 9.1 nM 8.04
CHEMBL4176614 IC50 = 9.5 nM 8.02
CHEMBL4164921 IC50 = 15.5 nM 7.81
CHEMBL4165247 IC50 = 18.5 nM 7.73
CHEMBL107 COLCHICINE IC50 = 38.2 nM 7.42
CHEMBL4172099 IC50 = 43.1 nM 7.37
CHEMBL4165657 IC50 = 43.4 nM 7.36
CHEMBL4175866 IC50 = 58.4 nM 7.23
CHEMBL4173581 IC50 = 82.4 nM 7.08
CHEMBL4177003 IC50 = 83.6 nM 7.08
CHEMBL4172091 IC50 = 87.2 nM 7.06
CHEMBL4169079 IC50 = 96.6 nM 7.01
CHEMBL4167665 IC50 = 185.5 nM 6.73
CHEMBL4168737 IC50 = 256.0 nM 6.59
CHEMBL4177343 IC50 = 363.3 nM 6.44
CHEMBL4175945 IC50 = 394.0 nM 6.41
CHEMBL4175532 IC50 = 442.6 nM 6.35
CHEMBL4168750 IC50 > 500.0 nM -
CHEMBL4164215 IC50 > 500.0 nM -
CHEMBL1091825 IC50 > 500.0 nM -
CHEMBL4160442 IC50 > 500.0 nM -
CHEMBL4160815 IC50 > 500.0 nM -
CHEMBL4165322 IC50 > 500.0 nM -