Assay Detail
Functional
CHEMBL4132295
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Antiproliferative activity against human HCT8 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.95 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166713 | — | — | 1 | 8.47 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.87 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.76 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166713 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 20.2 | nM | 7.70 |