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Assay Detail

CHEMBL4132435

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Binding
Inhibition of Respiratory syncytial virus Long fusion glycoprotein infected in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by spectrophotometric analysis
ChEMBL ↗
64
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Respiratory syncytial virus
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Fusion glycoprotein F0 (CHEMBL2364165) ↗
Type SINGLE PROTEIN
Organism Human respiratory syncytial virus

Publication

Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors.
Feng S, Li C, Chen D, Zheng X, Yun H, Gao L, Shen HC.
Eur J Med Chem (2017) 138 : 1147 -1157
PubMed 28772235 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 33 7.41 9.00
EC90 31 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4169195 — — 2 9.00
CHEMBL4172133 — — 1 8.70
CHEMBL4176374 — — 2 8.52
CHEMBL4164014 — — 2 8.52
CHEMBL4169599 — — 2 8.47
CHEMBL4161686 — — 2 8.40
CHEMBL4165762 — — 2 8.37
CHEMBL4174062 — — 2 8.30
CHEMBL4177457 — — 2 8.27
CHEMBL4175725 — — 2 8.15
CHEMBL4172317 — — 2 8.10
CHEMBL4175427 — — 2 8.00
CHEMBL4159228 — — 2 7.92
CHEMBL4173452 — — 2 7.92
CHEMBL4164254 — — 1 7.77
CHEMBL4171885 — — 2 7.60
CHEMBL243876 — — 2 7.55
CHEMBL4161267 — — 2 7.46
CHEMBL4160708 — — 2 7.28
CHEMBL4163349 — — 2 7.27
CHEMBL4160710 — — 2 7.12
CHEMBL4167137 — — 2 7.11
CHEMBL4165530 — — 2 7.06
CHEMBL4168630 — — 2 7.03
CHEMBL4177424 — — 2 7.00
CHEMBL4160615 — — 2 6.85
CHEMBL4167556 — — 2 6.75
CHEMBL4172993 — — 2 6.66
CHEMBL4170928 — — 2 6.54
CHEMBL4165109 — — 2 5.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4169195 — EC50 = 1.0 nM 9.00
CHEMBL4172133 — EC50 = 2.0 nM 8.70
CHEMBL4164014 — EC50 = 3.0 nM 8.52
CHEMBL4176374 — EC50 = 3.0 nM 8.52
CHEMBL4169599 — EC50 = 3.4 nM 8.47
CHEMBL4161686 — EC50 = 4.0 nM 8.40
CHEMBL4165762 — EC50 = 4.3 nM 8.37
CHEMBL4174062 — EC50 = 5.0 nM 8.30
CHEMBL4177457 — EC50 = 5.4 nM 8.27
CHEMBL4175725 — EC50 = 7.0 nM 8.15
CHEMBL4172317 — EC50 = 7.9 nM 8.10
CHEMBL4175427 — EC50 = 10.0 nM 8.00
CHEMBL4159228 — EC50 = 12.0 nM 7.92
CHEMBL4173452 — EC50 = 12.0 nM 7.92
CHEMBL4164254 — EC50 = 17.0 nM 7.77
CHEMBL4171885 — EC50 = 25.0 nM 7.60
CHEMBL243876 — EC50 = 28.0 nM 7.55
CHEMBL4161267 — EC50 = 35.0 nM 7.46
CHEMBL4160708 — EC50 = 53.0 nM 7.28
CHEMBL4163349 — EC50 = 54.0 nM 7.27
CHEMBL4160710 — EC50 = 75.0 nM 7.12
CHEMBL4167137 — EC50 = 78.0 nM 7.11
CHEMBL4165530 — EC50 = 88.0 nM 7.06
CHEMBL4168630 — EC50 = 93.0 nM 7.03
CHEMBL4177424 — EC50 = 100.0 nM 7.00
CHEMBL4160615 — EC50 = 140.0 nM 6.85
CHEMBL4167556 — EC50 = 180.0 nM 6.75
CHEMBL4172993 — EC50 = 221.0 nM 6.66
CHEMBL4170928 — EC50 = 290.0 nM 6.54
CHEMBL4165109 — EC50 = 1070.0 nM 5.97
CHEMBL4171983 — EC50 = 2414.0 nM 5.62
CHEMBL4164110 — EC50 = 5420.0 nM 5.27
CHEMBL4160323 — EC50 = 100000.0 nM 4.00
CHEMBL4161686 — EC90 = 0.006 uM -
CHEMBL4164110 — EC90 > 100.0 uM -
CHEMBL4165109 — EC90 = 4.84 uM -
CHEMBL4175725 — EC90 = 0.018 uM -
CHEMBL4173452 — EC90 = 0.027 uM -
CHEMBL4165530 — EC90 = 0.251 uM -
CHEMBL4161267 — EC90 = 0.045 uM -
CHEMBL4169195 — EC90 = 0.002 uM -
CHEMBL4176374 — EC90 = 0.004 uM -
CHEMBL4165762 — EC90 = 0.0059 uM -
CHEMBL4172993 — EC90 = 0.942 uM -
CHEMBL4160710 — EC90 = 0.307 uM -
CHEMBL4169599 — EC90 = 0.005 uM -
CHEMBL4177457 — EC90 = 0.021 uM -
CHEMBL243876 — EC90 = 0.42 uM -
CHEMBL4171983 — EC90 = 10.9 uM -
CHEMBL4172317 — EC90 = 0.0158 uM -