Assay Detail
Functional
CHEMBL4132519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at full length human GLP1R expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 8.29 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428139 | — | — | 1 | 10.15 |
| CHEMBL4173061 | — | — | 1 | 9.07 |
| CHEMBL4159256 | — | — | 1 | 9.03 |
| CHEMBL4163714 | — | — | 1 | 8.85 |
| CHEMBL4162383 | — | — | 1 | 8.80 |
| CHEMBL4161800 | — | — | 1 | 8.76 |
| CHEMBL4167169 | — | — | 1 | 8.73 |
| CHEMBL4177064 | — | — | 1 | 8.70 |
| CHEMBL4165144 | — | — | 1 | 8.52 |
| CHEMBL4163731 | — | — | 1 | 8.52 |
| CHEMBL4175452 | — | — | 1 | 8.49 |
| CHEMBL4174154 | — | — | 1 | 8.48 |
| CHEMBL4166241 | — | — | 1 | 8.45 |
| CHEMBL4169653 | — | — | 1 | 8.34 |
| CHEMBL4174382 | — | — | 1 | 8.23 |
| CHEMBL4167331 | — | — | 1 | 8.21 |
| CHEMBL5314341 | GLUCAGON | 4.0 | 1 | 8.11 |
| CHEMBL4174404 | — | — | 1 | 8.05 |
| CHEMBL4160347 | — | — | 1 | 7.99 |
| CHEMBL4098545 | — | — | 1 | 7.92 |
| CHEMBL4172444 | — | — | 1 | 7.79 |
| CHEMBL4160365 | — | — | 1 | 7.53 |
| CHEMBL4159426 | — | — | 1 | 7.50 |
| CHEMBL4159275 | — | — | 1 | 7.29 |
| CHEMBL4159003 | — | — | 1 | 7.05 |
| CHEMBL4170976 | — | — | 1 | 6.95 |
| CHEMBL4162789 | — | — | 1 | - |
| CHEMBL4170727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428139 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4173061 | — | EC50 | = | 0.86 | nM | 9.07 |
| CHEMBL4159256 | — | EC50 | = | 0.94 | nM | 9.03 |
| CHEMBL4163714 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4162383 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4161800 | — | EC50 | = | 1.72 | nM | 8.76 |
| CHEMBL4167169 | — | EC50 | = | 1.84 | nM | 8.73 |
| CHEMBL4177064 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4165144 | — | EC50 | = | 3.01 | nM | 8.52 |
| CHEMBL4163731 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4175452 | — | EC50 | = | 3.21 | nM | 8.49 |
| CHEMBL4174154 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4166241 | — | EC50 | = | 3.58 | nM | 8.45 |
| CHEMBL4169653 | — | EC50 | = | 4.54 | nM | 8.34 |
| CHEMBL4174382 | — | EC50 | = | 5.86 | nM | 8.23 |
| CHEMBL4167331 | — | EC50 | = | 6.14 | nM | 8.21 |
| CHEMBL5314341 | GLUCAGON | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4174404 | — | EC50 | = | 8.96 | nM | 8.05 |
| CHEMBL4160347 | — | EC50 | = | 10.31 | nM | 7.99 |
| CHEMBL4098545 | — | EC50 | = | 12.17 | nM | 7.92 |
| CHEMBL4172444 | — | EC50 | = | 16.16 | nM | 7.79 |
| CHEMBL4160365 | — | EC50 | = | 29.4 | nM | 7.53 |
| CHEMBL4159426 | — | EC50 | = | 31.93 | nM | 7.50 |
| CHEMBL4159275 | — | EC50 | = | 51.72 | nM | 7.29 |
| CHEMBL4159003 | — | EC50 | = | 88.23 | nM | 7.05 |
| CHEMBL4170976 | — | EC50 | = | 112.03 | nM | 6.95 |
| CHEMBL4162789 | — | EC50 | - | — | - | |
| CHEMBL4170727 | — | EC50 | - | — | - |