Assay Detail
Functional
CHEMBL4132520
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Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 8.57 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163714 | — | — | 1 | 9.34 |
| CHEMBL4170727 | — | — | 1 | 9.12 |
| CHEMBL4174154 | — | — | 1 | 9.07 |
| CHEMBL4166241 | — | — | 1 | 9.05 |
| CHEMBL5314341 | GLUCAGON | 4.0 | 1 | 9.01 |
| CHEMBL4098545 | — | — | 1 | 8.91 |
| CHEMBL4167331 | — | — | 1 | 8.90 |
| CHEMBL4162383 | — | — | 1 | 8.89 |
| CHEMBL4160347 | — | — | 1 | 8.85 |
| CHEMBL4159256 | — | — | 1 | 8.85 |
| CHEMBL4167169 | — | — | 1 | 8.85 |
| CHEMBL4173061 | — | — | 1 | 8.80 |
| CHEMBL4175452 | — | — | 1 | 8.78 |
| CHEMBL4169653 | — | — | 1 | 8.62 |
| CHEMBL4163731 | — | — | 1 | 8.55 |
| CHEMBL4174404 | — | — | 1 | 8.55 |
| CHEMBL4177064 | — | — | 1 | 8.52 |
| CHEMBL4172444 | — | — | 1 | 8.47 |
| CHEMBL4174382 | — | — | 1 | 8.41 |
| CHEMBL4165144 | — | — | 1 | 8.36 |
| CHEMBL4159003 | — | — | 1 | 8.35 |
| CHEMBL4160365 | — | — | 1 | 8.32 |
| CHEMBL4159426 | — | — | 1 | 8.28 |
| CHEMBL4161800 | — | — | 1 | 8.16 |
| CHEMBL4159275 | — | — | 1 | 7.84 |
| CHEMBL4170976 | — | — | 1 | 7.73 |
| CHEMBL4162789 | — | — | 1 | 6.91 |
| CHEMBL428139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163714 | — | EC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4170727 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4174154 | — | EC50 | = | 0.86 | nM | 9.07 |
| CHEMBL4166241 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5314341 | GLUCAGON | EC50 | = | 0.97 | nM | 9.01 |
| CHEMBL4098545 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL4167331 | — | EC50 | = | 1.27 | nM | 8.90 |
| CHEMBL4162383 | — | EC50 | = | 1.29 | nM | 8.89 |
| CHEMBL4160347 | — | EC50 | = | 1.41 | nM | 8.85 |
| CHEMBL4159256 | — | EC50 | = | 1.41 | nM | 8.85 |
| CHEMBL4167169 | — | EC50 | = | 1.43 | nM | 8.85 |
| CHEMBL4173061 | — | EC50 | = | 1.57 | nM | 8.80 |
| CHEMBL4175452 | — | EC50 | = | 1.68 | nM | 8.78 |
| CHEMBL4169653 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4163731 | — | EC50 | = | 2.84 | nM | 8.55 |
| CHEMBL4174404 | — | EC50 | = | 2.81 | nM | 8.55 |
| CHEMBL4177064 | — | EC50 | = | 2.99 | nM | 8.52 |
| CHEMBL4172444 | — | EC50 | = | 3.36 | nM | 8.47 |
| CHEMBL4174382 | — | EC50 | = | 3.88 | nM | 8.41 |
| CHEMBL4165144 | — | EC50 | = | 4.37 | nM | 8.36 |
| CHEMBL4159003 | — | EC50 | = | 4.49 | nM | 8.35 |
| CHEMBL4160365 | — | EC50 | = | 4.78 | nM | 8.32 |
| CHEMBL4159426 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4161800 | — | EC50 | = | 6.99 | nM | 8.16 |
| CHEMBL4159275 | — | EC50 | = | 14.6 | nM | 7.84 |
| CHEMBL4170976 | — | EC50 | = | 18.64 | nM | 7.73 |
| CHEMBL4162789 | — | EC50 | = | 122.57 | nM | 6.91 |
| CHEMBL428139 | — | EC50 | - | — | - |