Assay Detail
Binding
CHEMBL4132759
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Inhibition of human DPP4
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.54 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 8.70 |
| CHEMBL4176189 | — | — | 1 | 7.66 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.40 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 6.92 |
| CHEMBL98408 | — | — | 1 | 5.77 |
| CHEMBL383705 | — | — | 1 | 5.27 |
| CHEMBL397070 | — | — | 1 | 4.05 |
| CHEMBL98869 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4176189 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL98408 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL383705 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL397070 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL98869 | — | IC50 | = | 165000.0 | nM | - |