Assay Detail
Functional
CHEMBL4132828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CXCR4 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163246 | — | — | 1 | 9.00 |
| CHEMBL1088913 | — | — | 1 | 7.89 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163246 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1088913 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 44.0 | nM | 7.36 |