Assay Detail
Binding
CHEMBL4132832
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Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhodamine staining-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.56 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237830 | — | — | 1 | 9.52 |
| CHEMBL4162225 | — | — | 1 | 8.10 |
| CHEMBL4170138 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237830 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4162225 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4170138 | — | IC50 | = | 8.9 | nM | 8.05 |