Assay Detail
Functional
CHEMBL4132836
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Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.36 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168547 | — | — | 1 | 6.92 |
| CHEMBL4173028 | — | — | 1 | 6.72 |
| CHEMBL4176412 | — | — | 1 | 6.72 |
| CHEMBL4165124 | — | — | 1 | 6.00 |
| CHEMBL1381819 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168547 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4173028 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4176412 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4165124 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1381819 | — | IC50 | = | 3800.0 | nM | 5.42 |