Assay Detail
Functional
CHEMBL4132840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SW620 cells in folate free medium after 72 hrs in presence of leucovorin by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.38 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.66 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 7.05 |
| CHEMBL4162649 | — | — | 1 | 6.25 |
| CHEMBL4177183 | — | — | 1 | 6.11 |
| CHEMBL4166099 | — | — | 1 | 6.02 |
| CHEMBL4170578 | — | — | 1 | 6.01 |
| CHEMBL4163732 | — | — | 1 | 5.96 |
| CHEMBL4174018 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4162649 | — | IC50 | = | 563.0 | nM | 6.25 |
| CHEMBL4177183 | — | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL4166099 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL4170578 | — | IC50 | = | 977.0 | nM | 6.01 |
| CHEMBL4163732 | — | IC50 | = | 1102.0 | nM | 5.96 |
| CHEMBL4174018 | — | IC50 | = | 1137.0 | nM | 5.94 |