Assay Detail
Binding
CHEMBL4132886
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Inhibition of bovine liver arginase assessed as reduction in urea production using L-arginine as substrate after 60 mins in presence of MnCl2 by alpha-isonitrosopropiophenone reagent based spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cyperaceae Species Are Potential Sources of Natural Mammalian Arginase Inhibitors with Positive Effects on Vascular Function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.90 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1234777 | NOR-NOHA | 1.0 | 1 | 5.77 |
| CHEMBL4166673 | — | — | 1 | 4.91 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 4.90 |
| CHEMBL4174589 | — | — | 1 | 4.65 |
| CHEMBL4168211 | — | — | 1 | 4.60 |
| CHEMBL498439 | — | — | 1 | 4.56 |
| CHEMBL4167783 | — | — | 1 | - |
| CHEMBL1812995 | — | — | 1 | - |
| CHEMBL4176064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1234777 | NOR-NOHA | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4166673 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL69863 | PICEATANNOL | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4174589 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4168211 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL498439 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4167783 | — | IC50 | = | 182100.0 | nM | - |
| CHEMBL1812995 | — | IC50 | - | — | - | |
| CHEMBL4176064 | — | IC50 | - | — | - |