Assay Detail
Binding
CHEMBL4133215
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Displacement of bis-ANS to recombinant human MD2 after 5 mins by fluorescence assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| IC50 | 3 | 5.20 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176576 | — | — | 2 | 5.38 |
| CHEMBL4164940 | — | — | 2 | 5.17 |
| CHEMBL4162528 | — | — | 2 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176576 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL4164940 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL4162528 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4176576 | — | Inhibition | - | % | - | |
| CHEMBL4162528 | — | Inhibition | - | % | - | |
| CHEMBL4164940 | — | Inhibition | - | % | - |