Assay Detail
Binding
CHEMBL4133219
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Binding affinity to MD2 (unknown origin) by SPR assay
9
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 4.08 | 4.08 |
| Ka | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164940 | — | — | 3 | 4.08 |
| CHEMBL4176576 | — | — | 3 | - |
| CHEMBL4162528 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164940 | — | Kd | = | 84000.0 | nM | 4.08 |
| CHEMBL4176576 | — | Kd | = | 189000.0 | nM | - |
| CHEMBL4162528 | — | Kd | = | 125000.0 | nM | - |
| CHEMBL4176576 | — | Ka | = | 5860.0 | 1/Ms | - |
| CHEMBL4162528 | — | Ka | = | 5640.0 | 1/Ms | - |
| CHEMBL4164940 | — | Ka | = | 8240.0 | 1/Ms | - |
| CHEMBL4176576 | — | Kd | = | 1.11 | 1/s | - |
| CHEMBL4162528 | — | Kd | = | 0.703 | 1/s | - |
| CHEMBL4164940 | — | Kd | = | 0.695 | 1/s | - |