Assay Detail
Functional
CHEMBL4133568
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Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.13 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166887 | — | — | 1 | 4.17 |
| CHEMBL4174786 | — | — | 1 | 4.09 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166887 | — | IC50 | = | 67120.0 | nM | 4.17 |
| CHEMBL4174786 | — | IC50 | = | 81400.0 | nM | 4.09 |
| CHEMBL23588 | FLUFENAMIC ACID | IC50 | = | 115000.0 | nM | - |