Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4133604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.
Dissanayake AA, Ameen BAH, Nair MG.
J Nat Prod (2017) 80 : 2472 -2477
PubMed 28885836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.55 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL118 CELECOXIB 4.0 1 5.88
CHEMBL4166924 1 4.46
CHEMBL4173681 1 4.34
CHEMBL154 NAPROXEN 4.0 1 4.28
CHEMBL4170326 1 4.25
CHEMBL52229 OSTHOLE 1 4.09
CHEMBL4159700 1 -
CHEMBL25 ASPIRIN 4.0 1 -
CHEMBL521 IBUPROFEN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL118 CELECOXIB IC50 = 1310.0 nM 5.88
CHEMBL4166924 IC50 = 34600.0 nM 4.46
CHEMBL4173681 IC50 = 45300.0 nM 4.34
CHEMBL154 NAPROXEN IC50 = 52200.0 nM 4.28
CHEMBL4170326 IC50 = 56400.0 nM 4.25
CHEMBL52229 OSTHOLE IC50 = 81100.0 nM 4.09
CHEMBL4159700 IC50 - -
CHEMBL25 ASPIRIN IC50 - -
CHEMBL521 IBUPROFEN IC50 - -